1 answer

Which of the following metabolic reactions are possible for procainamide, shown below? O-dealkylation Hydrolysis Acetylation N-dealkylation...

Question:

Which of the following metabolic reactions are possible for procainamide, shown below?

ZI H2N

O-dealkylation

Hydrolysis

Acetylation

N-dealkylation

ZI H2N

Answers

Correct options:

O-dealkylation

Hydrolysis

Acetylation

Explanation:

Procainamide has an amide bond (N(H)-CO). Hence, hydrolysis of amide is a possible metabolic reaction.

Procainamide has an amine (NH2) functional group. Hence, acetylation of amine is a possible metabolic reaction.

Procainamide has an tertiary amine (NR3) functional group (R = alkyl). Hence, N-dealkylation of amine is a possible metabolic reaction.

There is no O-R group in the structure of procainamide . Hence, O-dealkylation is not possible.

.

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