# What is the mode of inheritance for hypercholesterolemia? a. Autosomal dominant b. Autosomal recessive c. X-linked...

###### Question:

What is the mode of inheritance for hypercholesterolemia?

a.

Autosomal dominant

b.

Autosomal recessive

c.

d.

e.

More than one of the above are possible

----------------------------------------------------------------

What is the mode of inheritance for Hunter's syndrome?

a.

Autosomal dominant

b.

Autosomal recessive

c.

d.

e.

More than one of the above are possible.

------------------------------------------------------------

What is the genotype for individual II-3 at the hypercholesterolemia locus (dominant allele is denoted by H, recessive allele is denoted by h)?

a.

HH

b.

Hh

c.

hh

d.

More than one of the above are possible

--------------------------------------------------------

If individuals III-4 and III-5 have two children, what is the probability that either one or the other (but not both) will have both hypercholesterolemia and Hunter's syndrome?

a.

1/2

b.

1/4

c.

1/8

d.

1/16

e.

1/32

f.

1/64

g.

None of the above

------------------------------------------

Xeroderma pigmentosum is an autosomal recessive trait that results in skin damage and higher incidences of skin cancer in affected individuals. While xeroderma pigmentosum is exceptionally rare in the general population, individuals I-3 and I-4 come from a population where the frequency of the disease allele for xeroderma pigmentosum is 1/320. What is the probability that individual IV-1 will exhibit xeroderma pigmentosum due to homozygosity by descent?

a.

1/102,400

b.

1/81,920

c.

1/20,480

d.

1/5,120

e.

None of the above

You are studying the inheritance of two traits in a family. In the family's pedigree shown below, a horizontal pink bar indicates that an individual is affected with hypercholesterolemia (high blood cholesterol levels). A vertical blue bar indicates that an individual is affected with Hunter's syndrome (a lysosomal storage disease). Individuals l-1 and 1-2 have no family history of Hunter's syndrome, but individuals 1-3 and 1-4 do. The genotypes of each individual are not known to you initially; you only know their phenotypes. Use this information to answer the following questions. - 2 3 4 = D- 1 2 3 4 5 6 D- 1 2 3 5 6 IV ? ? 1 N

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