1 answer

The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3...

Question:

The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3 hours, and volume of distribution 2 L/Kg. A 65 Kg patient requires an infusion in order to attain the plasmatic concentration of 6 mg/L. Recommend a loading dose and constant rate infusion (K0) for this treatment


Answers

ANSWER : Therapeutic window 4 - 8 mg/L, half-life 3 hours, volume of distribution 2 L/Kg.

A 65 Kg patient requires an infusion in order to attain the plasmatic concentration of 6 mg/L =

( (4+8)/2)*2*65*6 = 780 mg

(b) Infusion rate= (2*1000*65)/3

= 43333.33 ml/hr or 180.18 mg/hr

.

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