# QUESTION 18 Increased intracranial pressure in patients with traumatic brain injury is associated with a higher...

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QUESTION 18 Increased intracranial pressure in patients with traumatic brain injury is associated with a higher mortality rate and poor outcome. Mannitol and hypertonic saline (HTS) have both been used to treat high intracranial pressure, but it is unclear which one is more effective. Here, the authors compare the effect of mannitol versus HTS on lowering the daily intracranial pressure burden after severe traumatic brain injury. The reduction of intracranial pressure for 35 patients who received only HTS was 6 mmHg and 477 who received only mannitol was 13 mmHg. A hypothesis test comparing the two treatments had a p-value of 0.001. Write the conclusion of the hypothesis test.

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