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Please answer 8. Quaternary structure: The image below is of a polypeptide in quaternary (4°) structure...

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8. Quaternary structure: The image below is of a polypeptide in quaternary (4°) structure level of protein folding. The image
8. Quaternary structure: The image below is of a polypeptide in quaternary (4°) structure level of protein folding. The image to the left is of hemoglobin. It is composed of four separate polypeptide chains indicated by the color differences. The image on the right indicates the backbone items as a ribbon (or line), while the side chains are chemically drawn. a. Name the specific bond/interaction indicated by the: i. Letter A ii. Letter B iii. Letter C iv. Letter D b. Are these bonds/interactions/linkages covalent or non-covalent? c. Are these bonds/interactions permanent or transient? What parts of the amino acid (backbone or side chain) are involved in these bonds/interactions/linkages? e. Are these bonds/interactions/linkages between amino acids in the same polypeptide or different polypeptide? dB Three polypeptide chains CHCH. CH.CH E----- D (CH Quatemary structure: the four separate chains of hemoglobin assembled into an oligomeric protein os

Answers

a) Letter A : Ion induced dipole forces (by Fe in heme group) The Fe can bind to O group which helps heme unit to join other polypeptides

Letter B: Disulphide bond. These are bonds between two sulphur atoms.

Letter C: Hydrophobic interaction and Van der waals interaction

Letter D: Ionic Bond. These bonds are formed by the ionic state of atoms or molecules.

b) These are non-covalent bonds. There is no sharing of electron.

c) They are transient bonds. They may dissociate upon stress like heat.

d) The side chains are responsible for the interactions, as seen from the diagram.

e) The links are between different polypeptides

.

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