1 answer

Actice: Mutations - A -P--I--3--H--N--R--6--8- --11--11-- - ----- CGI GATTIOTITATITCATCCARAGATCTGGGC ATGACHATAGCTATCTACH --6-- -F-- - --5--5--K -3...

Question:

Actice: Mutations - A -P--I--3--H--N--R--6--8- --11--11-- - ----- CGI GATTIOTITATITCATCCARAGATCTGGGC ATGACHATAGCTATCTACH --6-0201 720(1).pdf Exam II Practice: Mutations III. Imagine that a different mutation in the TYR gene results in half of Exon 3

Actice: Mutations - A -P--I--3--H--N--R--6--8- --11--11-- - ----- CGI GATTIOTITATITCATCCARAGATCTGGGC ATGACHATAGCTATCTACH --6-- -F-- - --5--5--K -3 -4--G-- ----y--5--4--1--0 -- -- SOBOTACECCO THACACOLAGACICITITCAAGACTACATTAASTCCTATTTGGAACAAGCGAC CG 3 -D-P-- -- -- - -- -- --I--K -3-wY--1-- --0-- --3--2 MES CATCH.CCTCRIGGST SELCATOGICCITGGGGCCGCGADGGLAGGCGCSGTCC CACHGCOCTOCT 3GC --3-- -- -- -- -- -- - - -- 173 W 179 AGGCT GTGAGTT AGTIGCTGIGTCGI CACAAGAGAAAGCAGCTCCTGAAGAARSCAGOGI -s--1 -1 - 6 -R- -11--1--2--3--0--I -F - 6--6--8--0--p RTCCTCATCCAGAAGAGGA TACCACAGCHET 13 -1 1 -- --3--R-- -- - BAGGATACCACAGTGTATORGAGCCWT TATAA........ -- -- -- - - -- -- - Y-- - -- -- -- -- -- -- A person known to have albinism has a homozygous 1-basepair insertion in Exon 2 of the TRY gene. This mutation results in a premature STOP codon after amino acid residue #298. i What does "homozygous" mean in this problem? Having two identical alleles of a particular gene How many copies of the TYR gene are affected in this scenario? iii. How does this mutation result in a premature STOP codon? b. A person known to have albinism has a heterozygous mutation that results in pro81-lue substitution that interferes with normal folding of the tyrosinase protein. i. What does "heterozygous" mean in this problem? . How many copies of the TYR gene are affected in this scenario? iii. Do you think this person has a complete or partial lack of pigment? Explain your reasoning. tr = y = k, pro = P, led = [. C. Do people with albinism have the TYR gene? Do people without albinism have the TYR gene?
0201 720(1).pdf Exam II Practice: Mutations III. Imagine that a different mutation in the TYR gene results in half of Exon 3 being abnormally spliced out. Refer to this gene as TYR-splice The wild-type version of the TYR gene is referred to as TYR The TYR gene containing the frameshift mutation is referred to as TYR- You are being asked to compare the size of each macromolecule (DNA, mRNA and protein) of the two mutant TRY genes with the wild-type gene. Look at the blank spaces in the table that are not shaded. Each box gets filled in with a “yes” or “no” Consider the... What is the size of the TYR- compared to the TYR-WT ? What is the size of the TYR-splice compared to the TYR-WT? It is It is the same size as the It is bigger than the It is the same size as the wild- type It is smaller than the wild It is smaller than the wild-type bigger than the

Answers

A(i)homozygous- means identical alleles of a gene, this question tell us that there is a insertion of homozygous base pair in the exon2(coding portion as compared to intron which are spliced out in mRNA processisng)

(ii)all the copies of TYR gene are affected as this is a genetic change

(iii)stop codon are the nucleotide triplets in the mRNA that signals termination of translation of mRNA into proteins.example-UAG,UAA,UGA

without insertion mRNA- AUG-GCC-GGG-AAU-GAG

with insertion of A    - AUG-GCC-GGG-AAA-UGA-G

with insertion of a nucleotide or basepair the reading frame shifts leading to frame shift mutation, which might code for a stop codon which was not there in intital mRNA. this will lead to a shorter protein size as comapred to wild type mRNA

B(i) in this heterozygous means two different alleles are present, one is a functional copy and other is nonfunctional

(ii)one copy is affected

(iii)persond should have partial lack of pigmentation as one functional copy of the gene will produce tyrosinase which is functional and help in production of melanin (responisble for pigment formation)

C. all the people have TYR gene which codes for tyrosinase however in the people with albinism the activity of the enzyme is reduced if they have only one functional copy(heterozygous) due to mutations or complete lack of activtiy in homozygous situation.

III.TYR(fs)-variable length protein, if frame shift leads to stop codon then there will be premature termination

mRNA and gene length will be almost similar as compared to WT

TYR(spliced)similar gene length as to WT

matured mRNA will be shorter then WT

incomplete will be coded by the TYR(spliced)

.

Similar Solved Questions

1 answer
Chapter 9 A 6 Help Save & Exit Bartosiewicz Clinic uses client visits as its measure...
Chapter 9 A 6 Help Save & Exit Bartosiewicz Clinic uses client visits as its measure of activity. During January, the clinic budgeted for 3.500 client visits, but its actual level of activity was 3.490 client visits. The clinic has provided the following data concerning the formulas used in its ...
1 answer
What is the advantage and disadvantage for partial materialized view Please type it in computer
what is the advantage and disadvantage for partial materialized view Please type it in computer...
1 answer
How do i put on bell shape curve if my Tstat is -1.105 and Tcrit is...
how do i put on bell shape curve if my Tstat is -1.105 and Tcrit is 2.06 on a tailed...
1 answer
Problem 9-09 Presented below is information related to Cheyenne Inc. Cost $ 253,300 927,853 59,900 18,300...
Problem 9-09 Presented below is information related to Cheyenne Inc. Cost $ 253,300 927,853 59,900 18,300 Retail $394,400 1,482,100 79,400 | Inventory, 12/31/20 Purchases Purchase returns Purchase discounts Gross sales revenue Sales returns Markups Markup cancellations Markdowns Markdown cancellatio...
1 answer
What are recommendations on the existence of an HCM section in an organisation
what are recommendations on the existence of an HCM section in an organisation...
1 answer
Please answer all three questions Question 1 (1 point) In an exothermic gas compression, 22.1 kJ...
please answer all three questions Question 1 (1 point) In an exothermic gas compression, 22.1 kJ of heat and 7.6 kJ of work are exchanged between the system and its surroundings. What is the overall change in internal energy for the system? 0-14.5 kJ 29.7 kJ O-29.7 kJ 14.5 kJ Question 2 (1 point) 3...
1 answer
Assume the data Z 7n1 Z1 come from the AR(1) model where øl< 1 and at i.i.d. N(0,1). Give the exact conditional log- likelihood function for φ. Assume the data Z 7n1 Z1 come from the AR(1) mo...
Assume the data Z 7n1 Z1 come from the AR(1) model where øl< 1 and at i.i.d. N(0,1). Give the exact conditional log- likelihood function for φ. Assume the data Z 7n1 Z1 come from the AR(1) model where øl...
1 answer
As a long-term investment at the beginning of the 2018 fiscal year, Florists International purchased 20%...
As a long-term investment at the beginning of the 2018 fiscal year, Florists International purchased 20% of Nursery Supplies Inc.’s 5 million shares for $20 million. The fair value and book value of the shares were the same at that time. The company realizes that this investment typically woul...
1 answer
In the cash budget, the cash excess (surplus) or deficiency (deficit) is calculated using which of...
in the cash budget, the cash excess (surplus) or deficiency (deficit) is calculated using which of the following formulas...
1 answer
3. [0.34/1 Points] DETAILS PREVIOUS ANSWERS SCALCET8 5.1.014. The table shows speedometer readings at 10-second intervals...
3. [0.34/1 Points] DETAILS PREVIOUS ANSWERS SCALCET8 5.1.014. The table shows speedometer readings at 10-second intervals during a 1-minute period for a car racing at the Daytona International Speedway in Florida. Time (s) Velocity (mi/h) 0 181.9 10 168.0 20 105.6 30 98.8 40 123.5 50 175.1 60 175.6 ...
1 answer
Chapter 2 Quiz Saved 8 Moody Corporation uses a job-order costing system with a plantwide predetermined...
Chapter 2 Quiz Saved 8 Moody Corporation uses a job-order costing system with a plantwide predetermined overhead rate based on machine-hours. At the beginning of the year, the company made the following estimates: 3 points Machine-hours required to support estimated production Fixed manufacturing ov...
1 answer
A storage container is 22 inches long. 22 inches wide, and 24 inches deep. What is the volume of the container?
A storage container is 22 inches long. 22 inches wide, and 24 inches deep. What is the volume of the container?...
1 answer
4. Finish the synthetic route below to complete this transformation, by filling in reagents and intermediates...
4. Finish the synthetic route below to complete this transformation, by filling in reagents and intermediates in the boxes. OEt OEt OEt NaOET EtOH heat DH...
1 answer
You are standing in air and are looking at a flat piece of glass (n =...
You are standing in air and are looking at a flat piece of glass (n = 1.52) on which there is a layer of transparent plastic (n = 1.61). Light whose wavelength is 647 nm in vacuum is incident nearly perpendicularly on the coated glass and reflects into your eyes. The layer of plastic looks dark. Fin...
1 answer
E 53. A. Write the Lewis structure for: BCI What is its formal charge? 8. Structure...
E 53. A. Write the Lewis structure for: BCI What is its formal charge? 8. Structure Cl Item CI Valence Electrons Nonbonded Electrons (Bonded Electrons) ( Bonded Electrons) Formal Charge F 54. A. Write the Lewis structure for: SeF4 DATE: Te B. What is its formal charge? Structure Item Se Valence Elec...
1 answer
Can someone help me with this physics Lab Vibrating String Experiment I'm confused please and thank...
can someone help me with this physics Lab Vibrating String Experiment I'm confused please and thank you I have This data for the Five-time I did the Experience Vibrating String Experiment Objective To study the factors affecting the velocity of waves in a stretched string. Apparatus Linear tra...