1 answer

A DNA coding sequence of ATGCGTGGA(sequence for the rest of the gene)AATTAA encodes a protein chain...

Question:

A DNA coding sequence of ATGCGTGGA(sequence for the rest of the gene)AATTAA encodes a protein chain of 200 amino acids of MET-ARG-GLY-(196 more amino acids)-ASN after splicing. A mutation occurs in which the third G is changed to a T. Using the genetic code below, determine which type of mutation this is and briefly explain how translation will be affected for this protein chain.


Answers

As the mutation occurs in G, a purine to T,a pyrimidine- it is a transversion type of point mutation.

In the DNA sequence - ATGCGTGGA-, the mRNA having -AUG- codon in first,codes for the amino acid Methionine,which is the START CODON. So when this codon is present,the translation will start. But when the third G is mutated to T; the mRNA will have the codon sequence -AUU-, which codes for Isoleucine. So, from there the translation will not start.

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