19. Which of these molecules is activated by Akt? A) Ras b) JAK-2 c) IP3 d)...

Q)

A)

19.

The all molecules are activate by AKT only.

A)Ras

Ras is consitituvely activated by AKT and it significantly decresing the cholestrol deplition induces apoptosis in HT-29 , where abrogation of Akt is expressing in HCT_166 sense those cells are very sensitive to an apoptosis by cholestrol deplition.

B)JAK-2

JAK V617F mutation will only leads to an activation of JAK-2 STAT , P13K AND AKT PATHWAYS.

C) IP3

singnaling by AKT is one of the main key outcomes of an activation.

D)GLUT-4

it is only responsible for an glucose uptake in the skeletal muscles. where as the insulin induced translocation requires an PP3 KINASE activation.this is how AKT activate GLUT-4 .

20.

CALMODULIN is the one which act as an second messenger in ca⁺² . the binding protein of calcium plays an important role in physiological roles.It is founf in n eukaryotic organism

This binding of calcium can be intracellular or extracellular .In which intracellular cells contain lack of an structural EF hand domain . Where as the extracellular are classified in 6 groups.

Hence calmodulin is an multifunctional intermediate of an calcium binding protein .